Xanthurenic Acid in Depression
نویسنده
چکیده
An altered or increased excretion of xanthurenic acid (XA) in urine for 24h after intake of 5 grams L-tryptophan (Trp) at 10:00 p.m. is considered a measure of strain in the organism. XA was studied in 104 hospitalized depressive patients (DSM-HI : 296.23; 296.33) and 15 controls. Zung anxiety and depression scales were rated. The XA-excretion after Trp load has a wider range than the blank XA-excretion. The XAexcretion has decreased after 1 week's treatment with antidepressants, but has not decreased any further after 2 weeks' treatment, unless pryidoxine is administered between week 1 and 2. The XA-excretion after 1 week shows some correlation (r-0.272; p = 0.021) with the level of anxiety, the psychic aspect of strain. Possible reasons for this weak correlation are discussed.
منابع مشابه
Lens epithelial cell apoptosis and intracellular Ca2+ increase in the presence of xanthurenic acid
BACKGROUND Xanthurenic acid is an endogenous product of tryptophan degradation by indoleamine 2,3-dioxygenase (IDO). We have previously reported that IDO is present in mammalian lenses, and xanthurenic acid is accumulated in the lenses with aging. Here, we studied the involvement of xanthurenic acid in the human lens epithelial cell physiology. METHODS Human lens epithelial cells primary cult...
متن کاملDiuresis by intravenous administration of xanthurenic acid in rats, and inhibition by probenecid.
The conjugates with sulfate and glucoside of xanthurenic acid, a tryptophan metabolite, were reported to show natriuresis. Sulfotransferase for xanthurenic acid works in the renal proximal tubule to produce the sulfate of xanthurenic acid as well as the liver, and we recently found that xanthurenic acid is a substrate of renal organic anion transporter OAT1. The purpose of this study was to exa...
متن کاملA new automated determination of xanthurenic acid in human urine.
An automated determination for xanthurenic acid in urine was devised based upon its reaction with 2,6-dichioroquinonechlorimide. The separation of xanthurenic acid from interfering substances, such as urine chromogens and phenolic compounds other than xanthurenic acid, was performed by using Sephadex C-UI. The effluents containing the xanthurenic acid were determined automatically. As a result ...
متن کاملXanthurenic Acid 8-O-&~-Glucoside, a Novel Tryptophan Metabolite in Eye-color Mutants of Drosophila meZanogaster*
An unknown fluorescent metabolite has been isolated from heads of eye-color mutants of Drosophila melanogaster. Only a few mutations cause it to accumulate, uiz. cardinal (cd), dark red brown (drb), Henna-recessive (Hn’), purple (pr), Punch2 (Pu’), Punch-Grape (Puff’), and scarlet (st). After purification by ion-exchange chromatography, the spectroscopic, chemical, and enzymatic analyses reveal...
متن کاملKynurenine metabolism and xanthurenic acid formation in vitamin B6-deficient rat after tryptophan injection.
Normal and vitamin B6-deficient rats received an intraperitoneal injection of 30 mg/100g of body wt, and the contents of metabolites in kidney or plasma and the related enzyme activities in kidney were determined. The contents of kynurenine and 3-hydroxykynurenine in B6-deficient rat plasma and kidney were much higher than those in normal rat. The changes of those contents in plasma were parall...
متن کامل